Gene therapy trial for skin cancer cures two terminal patients

Friday, September 1, 2006 

Results of gene therapy trials at the US National Cancer Institute, Bethesda to fight cancer published online yesterday by the scientific journal Science show some levels of success. However experts have warned that despite the promise more work is needed for this to become a viable cure.

Dr Stephen Rosenberg, who lead the research team, said “It’s important to emphasize this is a highly experimental treatment that’s still in the course of development.”

The team treated 17 terminal skin cancer patients with modified cells from their immune systems. The technique uses genetically modified white blood cells (more specifically T cells) to attack and kill the cancer cells. Of the 17 subjects only 2 were cured of the disease (an aggressive form of skin cancer called a melanoma which is usually fatal in advanced stages). Before the treatment, which lasted 18 months, the patients were only expected to live for up to 6 months. The remaining 15 patients were not affected by the treatment.

One of the successful patients was Mark Origer (53) from Wisconsin. He has been fighting cancer since first being diagnosed in 1999. After finding out about the new trial on the internet he applied and, after interviews, was accepted along with 16 other candidates. The treatment removed Origer’s melanoma and also shrunk another tumor in his liver – to the extent it could be removed surgically. Doctors confirmed he was free of the disease last week, nearly 2 years after treatment began. A second man (39) was cleared of his cancer which had spread to the lungs, liver and lymph nodes. Cancer that progresses to the lymph nodes is usually untreatable and fatal.

T cells can attack and destroy bacteria and other harmful cells like cancer cells. However cancer cells sometimes reduce the signals on their outer surface by which they are recognised, so the immune system cannot affect them. Gene therapy involves modifying some of a patients T cells to contain a new receptor. (Receptors are what enable the immune cell to identify harmful cells, like those corrupted by viruses. The new receptor is inserted with the use of a viral vector, i.e. a virus made safe to insert the receptor in the cell.

In the trial, T Cells were removed from each patient and modified in the laboratory. Patients underwent chemotherapy to kill most of their current immune system, which was replaced by the mutated cells. The modified cells successfully survived after injection into the body – making up 10% of the subject’s T cell count during the first 2 months. The team is now looking for ways to enable the cells to survive longer and in greater numbers.

Experts have called this a significant technical advance but warn that more patients need testing and the technique refining before any conclusive results can be drawn. Dr Edel O’Toole, consultant dermatologist and British Skin Foundation spokesman, said: “I think that the success of this approach in two patients shows promise, however 15 patients did not respond to the treatment suggesting that further work is needed to optimise this approach for all patients, which could take many years.”

Rosenberg now hopes to run a new trial with possibly stronger gene therapy treatments, he is currently awaiting FDA approval.

Gene therapy was much hyped after it’s first successful application in so called “bubble boys” (patients with severe combined immunodeficiency). After follow-up, these trials were stopped when it was discovered that three of eleven patients in one trial had developed leukemia.



Gene therapy trial for skin cancer cures two terminal patients

Friday, September 1, 2006 

Results of gene therapy trials at the US National Cancer Institute, Bethesda to fight cancer published online yesterday by the scientific journal Science show some levels of success. However experts have warned that despite the promise more work is needed for this to become a viable cure.

Dr Stephen Rosenberg, who lead the research team, said “It’s important to emphasize this is a highly experimental treatment that’s still in the course of development.”

The team treated 17 terminal skin cancer patients with modified cells from their immune systems. The technique uses genetically modified white blood cells (more specifically T cells) to attack and kill the cancer cells. Of the 17 subjects only 2 were cured of the disease (an aggressive form of skin cancer called a melanoma which is usually fatal in advanced stages). Before the treatment, which lasted 18 months, the patients were only expected to live for up to 6 months. The remaining 15 patients were not affected by the treatment.

One of the successful patients was Mark Origer (53) from Wisconsin. He has been fighting cancer since first being diagnosed in 1999. After finding out about the new trial on the internet he applied and, after interviews, was accepted along with 16 other candidates. The treatment removed Origer’s melanoma and also shrunk another tumor in his liver – to the extent it could be removed surgically. Doctors confirmed he was free of the disease last week, nearly 2 years after treatment began. A second man (39) was cleared of his cancer which had spread to the lungs, liver and lymph nodes. Cancer that progresses to the lymph nodes is usually untreatable and fatal.

T cells can attack and destroy bacteria and other harmful cells like cancer cells. However cancer cells sometimes reduce the signals on their outer surface by which they are recognised, so the immune system cannot affect them. Gene therapy involves modifying some of a patients T cells to contain a new receptor. (Receptors are what enable the immune cell to identify harmful cells, like those corrupted by viruses. The new receptor is inserted with the use of a viral vector, i.e. a virus made safe to insert the receptor in the cell.

In the trial, T Cells were removed from each patient and modified in the laboratory. Patients underwent chemotherapy to kill most of their current immune system, which was replaced by the mutated cells. The modified cells successfully survived after injection into the body – making up 10% of the subject’s T cell count during the first 2 months. The team is now looking for ways to enable the cells to survive longer and in greater numbers.

Experts have called this a significant technical advance but warn that more patients need testing and the technique refining before any conclusive results can be drawn. Dr Edel O’Toole, consultant dermatologist and British Skin Foundation spokesman, said: “I think that the success of this approach in two patients shows promise, however 15 patients did not respond to the treatment suggesting that further work is needed to optimise this approach for all patients, which could take many years.”

Rosenberg now hopes to run a new trial with possibly stronger gene therapy treatments, he is currently awaiting FDA approval.

Gene therapy was much hyped after it’s first successful application in so called “bubble boys” (patients with severe combined immunodeficiency). After follow-up, these trials were stopped when it was discovered that three of eleven patients in one trial had developed leukemia.



New Zealand medical student funding to be reviewed

Monday, February 20, 2006 

The New Zealand government has announced that it will be reviewing funding for medical and dentistry students at Otago and Auckland Universities to certify the institutions’ standards and help staff retention.

The dean of Auckland University’s Faculty of Medical and Health Sciences, Professor Iain Martin says the review “can’t come soon enough”.

The Medical Students Association welcomes the review. It says that it has been worried about student debt for years “High debt encourages too many graduates overseas, or into high paying areas of practice at the expense of areas like general practice”



7 Creative Uses Of A Storage Shed

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By J.C. Mims

Storage sheds have many uses other than just storage. While storage is what they are designed for, they can easily be transformed into a structure with as many uses as the imagination allows.

After being involved in the storage shed business for nearly two decades I have seen many creative uses for storage buildings.

The following are the Top 7 uses for a storage shed:

7. Temporary house Use a storage building as a temporary home while building a new home on some land, and then use the storage building as a home office. A large storage shed can easily become an efficiency apartment without much extra expense. You can easily insulate the building and add paneling. Put up temporary walls, add a kitchenette, and complete it with a bathroom in the corner with toilet and a stand up shower. Nothing fancy, but still enough to get by.

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6. Cabin Got some land that you like to spend time at on the weekends, but not enough to warrant investing to build a new cabin? A large finished out storage building can easily become a cabin with all the bare necessities. (see #7 above for further detail).

5. Barbershop enjoy cutting hair on your own schedule? A storage shed can easily be equipped to become a barbershop. Best of all, your office is now in your backyard. You can add landscaping and accents to add your own personal charm to your new office that will keep your customers coming back.

4. Snow-cone Stand Take a small 8×8 or similar size shed, add some sliding windows to the front, add some shelves, a couple of plugs, and possibly an air conditioner, and you have a quick, inexpensive, seasonal business. Best of all, it is relatively easy to relocate your business from one place to another. You can even leave the shed on a trailer and move it from place to place with ease. Set it up at baseball games, city events, football games, etc

3. Craft Shed Need a place to do your craftwork without having to clean it up and store it away every time you use it? A small storage building can be customized with shelves and all the essentials to meet your needs. No more clean up required.

2. Workshop Have plenty of tools, but dont ever use them because it is too much work to get them out of storage each time? You can customize a storage shed to become a workshop. That way, you can keep everything in eyesight right where you need it. You will find you use all those tools you couldnt live without much more when they are easily accessible.

1. Storage Shed Used as a typical storage shed. The most common uses include lawn and garden equipment storage, atv

storage, furniture storage, and basically anything you are not ready to throw out yet.

As you can see, with a little imagination a storage shed can become so much more than a storage shed. Most people would never imagine you could use a storage shed as a cabin or temporary home. But, having built a number of these for customers I can say first hand that they are surprisingly cozy. Naturally, this is not a long term solution, but it is definitely a cost effective solution to a short term problem.

That is my top 7 (maybe not so common) uses of a storage shed.

About the Author: Visit

my-backyard-projects.com

for more storage shed and backyard project information.

Source:

isnare.com

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Discovery sheds light on flow of water in carbon nanotubes

Wednesday, September 17, 2008 

Experiments during the past several years examining membranes formed from carbon nanotubes have demonstrated potential for a variety of applications, perhaps most notably economical filtration of water for desalination. But something that has consistently confused researchers is that the rate of flow for water passing through these special membranes is considerably higher than would be predicted by classical physics. In some experiments the flow rate was up to 10,000 times the speed expected. In addition, recent measurements by a team at Lawrence Livermore National Laboratory conducted via nuclear magnetic resonance showed that the water passing through nanotubes exhibits very different properties in comparison to bulk water.

In a press release Tuesday the News Bureau of the University of Illinois at Urbana-Champaign highlighted a recent finding that offers one possible explanation for the phenomenon. The research, published in Physical Review Letters last month (doi:10.1103/PhysRevLett.101.064502 ), used molecular modeling to analyze the predicted behavior and interactions of individual water molecules passing through a nanotube.

UIUC researchers Narayana R. Aluru, a professor of mechanical science and engineering, and doctoral student Sony Joseph found that the chemical polarity of H2O and what they describe as “confinement effects” within the bounds of smaller nanotubes cause the molecular movements to couple. Due to the water molecules interacting and orienting themselves in response to one another they flow in a more orderly helical or corkscrew pattern through the nanotube. This flow pattern may explain some of the experimental results obtained by other scientists.

Hopefully this discovery is another step towards an affordable technology to produce plentiful potable water for drinking, irrigation of crops, and other purposes, a vital resource that is in short supply in many parts of the world.



Doctors who treated John Ritter cleared of negligence lawsuit

Friday, March 14, 2008 

Two doctors who treated actor John Ritter for chest pain in Burbank, California were cleared of a negligence lawsuit on Friday. Ritter was an American television and film actor who died of aortic dissection on 11 September 2003.

Ritter’s children and widow (Amy Yasbeck) filed a US$67 million lawsuit claiming negligence by the doctors, both at the time Ritter fell ill and at a medical checkup two years earlier where problems with Ritter’s aorta could have been spotted.

A jury hearing the case at Los Angeles County Superior Court voted 9-3 to dismiss the claims, satisfied that the defendants, Dr. Joseph Lee and Dr. Matthew Lotysch, acted properly during their examination and treatment of Ritter.

Ritter’s last role was in leading the cast of the television series 8 Simple Rules for Dating My Teenage Daughter whose production was disrupted by his death.



David Tennant announces exit from Doctor Who

Thursday, October 30, 2008 

Actor David Tennant made an announcement Wednesday at the National Television Awards in the United Kingdom that he will end his time portraying the Tenth Doctor on the long-running BBC science fiction drama Doctor Who in 2009. The announcement came as part of Tennant’s speech accepting the outstanding drama performance award at the program.

Tennant, 37, is currently portraying the lead in a production of Hamlet with the Royal Shakespeare Company, and accepted the award by videolink. He was up against Doctor Who co-star Catherine Tate, who portrayed his companion Donna Noble. Doctor Who was recognized with the award for most popular drama program.

“I love this part, and I love this show so much that if I don’t take a deep breath and move on now I never will, and you’ll be wheeling me out of the Tardis in my bath chair,” said Tennant in his address to the audience in attendance at the Royal Albert Hall. “TARDIS” refers to the time machine and spacecraft operated by Tennant’s character known only as “the Doctor”, and stands for Time And Relative Dimension In Space.

Tennant will again inhabit the TARDIS as the Tenth Doctor for the upcoming Doctor Who Christmas special, “The Next Doctor”, and will portray the Doctor in four additional specials set to air in 2009. A new actor will play the Doctor for the program’s 2010 series.

Tennant had initially been interested in portraying the Doctor in the 2005 series, but that role went to Christopher Eccleston. The series had previously been dormant since 1996, with Paul McGann in the lead role. Tennant has said that it was his childhood dream to play the Doctor. This is not his first time being recognized at the National Television Awards for his role as the Doctor. In 2006 he received the award for most popular actor, and again in 2007. In 2006 Tennant beat out actor Tom Baker as the favorite doctor, in a survey of readers of Doctor Who Magazine.

The Doctor comes from a race of Timelords, and has the ability to “regenerate” and change appearance when his health is failing. Actors including Russell Tovey, James Nesbitt, Paterson Joseph, John Simm and David Morrissey have been mentioned in the media as possibilities to portray the 11th incarnation of the Doctor.

Russell T. Davies, the program’s current executive producer, commented to BBC News on the end of the Tenth Doctor and his work with Tennant: “I’ve been lucky and honoured to work with David over the past few years – and it’s not over yet, the Tenth Doctor still has five spectacular hours left! After which, I might drop an anvil on his head. Or maybe a piano. A radioactive piano. But we’re planning the most enormous and spectacular ending, so keep watching.” Steven Moffat will replace Davies as executive director of Doctor Who in 2010.

Tennant began his work as an actor with roles in theatre, and progressed to starring roles on television programs including Blackpool and Casanova. He has recently returned to theatre roles with the Royal Shakespeare Company, and has received praise for his work in Hamlet and Love’s Labour’s Lost.



When Hiring An International Shipping Company

When Hiring an International Shipping company

by

croancottages

When you are hiring an international shipping company for household items, furniture items, automobiles, etc. amongst others, always check the credentials.

When you are hiring a shipping company to transport vehicles, furniture items, household items, etc. amongst others to various destinations in the US and worldwide, you need to keep certain factors in account. You can have several options to transport auto product hiring an international shipping company; however, you need take care that it is done by a reliable one. The company that offers assured delivery within a stipulated time period is the one that can be trusted irrespective of the charges and location.

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The best option suitable for international shipping, goods, household, etc. is to hire the one that has track record in collecting them from your location. It reduces any eventual damage to goods and household items that can happen while you are carrying them. It is better to hire and pay to professionals, as they know their jobs well and offer the needed services. Why to get involved in a job that you do not know; it will aggravate the situation and cause losses which you never desire when looking for international shipping of household items.

Thus, hiring an international shipping company that picks auto products and transfers the same to the shipyard and then finally delivers to the destination is the right decision you should consider. It not only reduces the chances of any damages but also eases the entire movement from destination to destination. The products or goods are delivered safely and securely which is what is required the most when you have started searching for the right shipping company.

Your requirement for international shipping, freight or household items can now be fulfilled by the professional services providers who know well what it amounts to deliver them to destinations. Most of these companies with trained and experienced staff tend to cater the requirement with professional approach and that is what matters the most in international shipping which is fast emerging as a competitive sector.

Nonetheless, the need for international shipping, household items, auto products, furniture items, etc. is the one that every now and then appears. Hiring the right shipping company for the job is essential for the obvious reason that it must be done considering several factors. The first priority should be to know whether the company provides shipping insurance for any damages that may occur during the transportation or shipping. Search the right international shipping company to avoid any disappointment that may ensue later on.

For Details

Car Security Alarm

&

International Automobile Shipping

or visit http://www.shippinginternational.com/

Article Source:

ArticleRich.com



Oil leaking container ship might cause environmental catastrophe

Sunday, January 21, 2007 

In the United Kingdom, an anti-pollution operation is under way after the stricken ship MSC Napoli started to leak dangerous heavy fuel oil.

The heavy fuel oil that is leaking from the beached Italian ship is extremely dangerous for the environment. Fear of pollution increased after the ship was further damaged during storms last Thursday. MSC Napoli was beached by Devon coastguards after it suffered heavy structual damage in the gale force storms of Thursday, 18 January 2007, that wreaked havoc across Northern Europe. The ship, which contains 160 containers of hazardous chemical substances, is listing at 35 degrees.

The entire 26-man crew was rescued by navy helicopters Thursday after severe gales. Cracks were found on both sides of the ship, but the current oil leak was not expected.

Around 2,400 containers were carried by the 62,000 tonne ship, some of which contain potentially dangerous hazardous chemicals.

The Coastguards have reported that up to 200 of the containers carrying materials such as perfume and battery acid are loose from the ship and they are looking for missing containers. South African stainless steel producer Columbus Stainless confirmed on Friday that there was at least 1,000 tonnes of nickel on board MSC Napoli.

A hole in the ship flooded the engine room and there’s now fears that the ship will break up. Saturday MSC Napoli was towed to Portland when a ”structural failure” forced the salvage team to beach it. As the storms have continued MSC Napoli has been further damaged.

The authorities have warned people about the pollution, which already has reached the beaches at Devon, but many want to see it on their own. Police have closed Branscombe Beach as more than 20 containers have broken up scattering their contents along the beach.

Sky News reported Sunday that the costs of the accident might be very high as thousands of pounds worth of BMW motorbikes, car parts, empty oak barrels and perfume might get lost in flooding containers.



Category:Merchant shipping

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